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Real-World Data (RWD) and Real-World Evidence (RWE) have an increasingly important role in decisional steps within the healthcare field. Knowing the complexity of this field is an important tool to benefit from the nowadays availability of clinical data. In our Real-World Data and Real-World Evidence courses, designed for professionals dealing with clinical trials, statistical analysis, and manuscripts among others, the concepts behind these two fields are addressed; the rationale behind the use of these data, how to collect RWD, statistical analysis and publication.