The EudraVigilance Data Analysis System (EVDAS) launched in 2018 represents a new and very important source for signal detection and signal evaluation in Europe by providing Marketing Authorisation Holders (MAH) access to one of the biggest pharmacovigilance database in the world. According to the Guidelines on Good Pharmacovigilance Practices (GVP) and other regulatory documents, EMA demands the obligatory use of this system for the evaluation of signals detected via other sources than EVDAS (so called external signals) and partly also for signal detection. Furthermore, EVDAS as additional source of information is intended to widen the MAH’s continuous benefit risk assessment of medicinal products. However, the new responsibilities like monitoring obligations as well as handling complex data sets, represent major challenges. Especially small and medium-sized enterprises (SMEs) are burdened with the heavy workload associated with the collection, review and assessment of the provided information. Therefore, it is crucial to find an approach to select the relevant information avoiding unnecessary steps. This online training course will provide a clear overview on different types of reports that can be retrieved from EVDAS as well as the use of the database regarding different aspects of signal management. Practical tips on analysis of EVDAS outputs (eRMRs & line listings) will be also provided within an interactive session during which the attendees will have the opportunity to ask questions.