Course linked to
European Statistical Forum | 14 November 2023 - Munich
"Statistical Methodology in Precision Medicine and the role of Artificial Intelligence"
Precision medicine is about going beyond assessing whether a new treatment works on average to predicting which subgroups of patients receive benefit and to what extent. Precision medicine offers substantial advantages to patients, trial sponsors, and the wider healthcare system.
However, a barrier to realising the promise of precision medicine is the inappropriate use of traditional clinical trial design and analysis, which rely on estimates of population-averaged effects.
In this course, we introduce the concept of precision medicine and cover some innovative approaches, including basket, umbrella, and platform trials, and the benefits of Bayesian approaches for the design/analysis of these trials. These trial design approaches have all been developed to improve power and patient benefit provided by clinical trials.
Examples from a wide variety of therapeutic areas will be discussed, with implementation in the OpenBUGS and R software.
Perspectives will be given on the future development of design, conduct and analysis of clinical trials in the field.