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https://lsacademy.com/wp-content/uploads/2020/09/img.jpg19201082In 2020 the revision of ICHE9 has became effective in the ICH regions. Beyond the immediate operational consequences in terms of study documentation development, it has become clearer and clearer that the introduction of the Estimand framework may require methodological solutions which were not common practice in drug development when the revised guidance was released. … Continued